Despite these differences, the consistent findings were that ABHD11 depletion or inhibition predominantly results in 2-OG and 2-HG accumulation and HIF-1 activation, which differed from conditions of glutarate excess
These enzymes maintain genome stability and integrity while glutathione prevents oxidative DNA damage
Kim EH, Shin D, Lee J, Jung AR, Roh JL
(2019) 144:10917.e4
Immune dysregulationparticularly involving T-helper cell imbalance, increased pro-inflammatory cytokines (e.g., TNF-, IL-6), and reduced regulatory T cell functionhas been shown to impair maternal-fetal tolerance
Pooled analyses of phase III studies of ADS-5102 (amantadine) extended-release capsules for dyskinesia in Parkinsons disease