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This is likely why retatrutides triple agonism works so well: it captures glucagons metabolic and lipid effects without causing high blood sugar

Some telehealth providers offer compounded versions (e.g., semaglutide), which may be cheaper but lack FDA approval

Lower-cost generic versions are available in 8 mg, 15 mg, 30 mg, and 37.5 mg doses

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Retatrutide versus tirzepatide This comparison is particularly relevant because tirzepatide already demonstrated significant improvements over semaglutide, making it the standard that retatrutide must beat

WIRED also reached out to a number of other telehealth companies offering oral semaglutide and tirzepatide, looking for more information about how they source these medications and what clinical evidence they use to back up assertions of efficacy, including Strut, Henry Meds, Willow, Zealthy, and Ivy RX, none of which responded to repeated requests for comment