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When a too high concentration of antioxidants (e.g., ascorbate) is used, a switch from antioxidant to prooxidant behavior may occur, especially under certain conditions (e.g., highly oxygenated tissues such as lungs or the presence of redox-active metals such as Cu or Fe)

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Morphological alterations to the mitochondria occur during ferroptosis when atrophy of the whole mitochondria and a decrease in mitochondrial cristae are seen

The mice in the GSH group received a subcutaneous injection of 0.5 mL 1 g/kg GSH on each side of the lower back for 3 consecutive days (-3, -2, and -1 days, prior to the start of the experiment), after which 0.2 mL of the prepared lipoaspirate was transplanted subcutaneously at the same sites of injection at day 0 of the experiment under anesthesia (Fig