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Losing too much muscle during rapid weight loss can slow down metabolism, leading the body to burn fewer calories at rest

The association between SGLT2 inhibitor use and falls remained an independent risk factor for falls even after adjusting for known risk factors for falls, such as history of falls, skeletal muscle mass, muscle strength, and retinopathy

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Additionally, patients using both treatments may attribute weight loss or adverse effects to the wrong agent, complicating clinical assessment

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Beyond the indirect benefits of weight loss on inflammation, research is also examining whether GLP-1 medications directly affect other inflammatory processes