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Low erythrocyte levels of GPX and GR among patients indicate that superoxides formed by antioxidants of various thiol-containing compounds (glutathione) result in decreased levels of GR

However, we must interpret these findings with caution, explicitly acknowledging the significant heterogeneity in study design, patient cohorts, and choice of comparator agents that characterizes the current body of literature

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Higher dosage is associated with more frequent gastrointestinal side effects