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In line with this, previous studies have shown that systemic -secretase inhibitor treatment prevents the release of A peptides into the extracellular space 51 , leads to a rapid decrease of total 30,52 and oligomeric 10 A levels in mouse models of -amyloidosis and, concomitantly, normalized neuronal activity 10

Total 10 patients developed liver cancer

Serious concerns with unregulated/high-dose use: infections from non-sterile settings, kidney or liver stress at very high doses over time, and (rarely) thyroid disruption

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