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While Wegovy makes fasting feel easy due to its impact on lowering hunger, this combination increases the risk of inadequate protein intake and accelerated muscle loss

Osteocytes secrete sclerostin in response to mechanical stress, which acts on the Wnt/-catenin pathway in osteoblasts to inhibit cell proliferation, impair mineralization, enhance apoptosis, and promote osteoclast formation and activity in a RANKL (receptor activator of nuclear factor B (NF-B) ligand)-dependent manner (Horwood, 2016)

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