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MIL-101 (Fe)@RSL3 NPs deliver iron ions and RSL3 to ccRCC cells, which generate large amounts of ROS through Fenton reactions, leading to the accumulation of LOX, and as GPX4 activity is inhibited by RSL3, this combination induces cell death by ferroptosis (171)

Falsetta ML, Klein MI, Colonne PM, Scott-Anne K, Gregoire S, Pai CH, et al

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[] A single-arm study investigated the safety, efficacy, pharmacodynamics, and pharmacokinetics of SFN-rich broccoli sprout extract given to 20 men