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Notably, the present narrative review is an extension of a previous review article that covered polyphenols and/or phytoestrogens that included daidzein, equol, genistein, and resveratrol as supplemental therapies for skin aging, which was published in Dermatology and Therapy earlier this year by Lephart (2025) [9]

GHK-Cu stimulates collagen synthesis and skin remodeling

J Accid Emerg Med

In 2006, the research-and-development arm of Pliva was acquired by GlaxoSmithKline, which has ample resources for clinical trials, but the company has not commercialized the peptide

Management generally involves levothyroxine replacement therapy, complemented in some cases by dietary optimization and micronutrient supplementation