Both GLP-1 drugs and bariatric surgery are known to improve blood sugar control, which is why semaglutide was originally approved as a treatment for type 2 diabetes
Ethics, reproducibility and methodological pitfalls Frequent pitfalls in cognitive peptide research No vehicle control in some old Russian studies: mandatory in any modern publication Non-randomisation : assigning animals to groups by order of arrival introduces systematic bias (weight, oestral cycle, cage stress) Non-blinded experimenter : behavioural tests are highly sensitive to expectations
As a result, we could not directly evaluate the potential implications of rapid glucose lowering for the observed outcomes, a mechanism hypothesized to contribute to the initial worsening of DR with GLP-1 RA use
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