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In this field of weight management, that little teeny part of the chart dictates so much of their care

Slower titration schedules and genetic profiles showing lower GLP1R sensitivity may require dose reductions or alternative compounds

Semaglutide, tirzepatide, and retatrutide (Biosynth, Compton, UK, lot #s 0000042482, 0000054911, and 0000205204 respectively) were dissolved in 0.3% phosphate-buffered saline (PBS), which was adjusted to a pH of 8.0 using NaOH and injected subcutaneously at 1 ml/kg

Be sure to talk to your team of healthcare providers for guidance on whether these medications are right for you

Interest in these medications has recently accelerated, largely for their weight-loss effects, although access to and use of GLP-1 RA medications may be impacted by high cost, limited insurance coverage for patients without T2D and medication shortages

This data is invaluable for troubleshooting and for conversations with your provider about dose adjustments