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For some men, they notice changes in weeks

2008;34:S73-7

These findings have been confirmed and extended by many other clinical trials with LH-RH agonists in patients with prostate cancer in North America and Europe 7,13

Since it is such a strong base, a deprotonated amine (confusingly also called an amide, or sometimes metal amide base) is pretty much the opposite of a decent leaving group