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Recognised risk factors are listed in Table 1

An additional mode of communication from the gut to the brain includes the enteric nervous system (ENS) and sensory neurons expressing receptors to TNF-, IL-1 or IL-6 (243), and to 5-HT (244), which is abundantly produced at the gut level (245) (upwards black arrows in Figure 2 )

Additional pro-thrombotic variables in PV considered over the last three decades include leukocytosis [64, 78,79,80,81], JAK2 V617F allele burden [65, 82] and intensity of phlebotomy [83, 84]

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Limited information is available regarding the use of CO Q Best-300 Tablet in children, so please consult a doctor

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