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However, it did significantly reduce the decrease in motor nerve conduction velocity and paw intraepidermal fiber density observed in diabetic mice through the activation of extracellular signal-regulated kinase (ERK) signaling [81]

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Tirzepatide (brand names Mounjaro, Zepbound) is a dual GIP/GLP-1 receptor agonist that produces higher average weight loss, roughly 18 to 25% of body weight in clinical trials