Although the GLP-1R agonists are used to treat type 2 diabetes in clinic ( 3.1 PKA/STAT3 pathway GLP-1 and its analogues exert their function such as M2 polarization by inducing the activation of the activator of transcription 3 (STAT3) ( via PKA-STAT3 signaling ( via the cAMP-PKA-STAT3 signaling pathway ( 3.2 MAPK and NF-B pathway Mitogen-activated protein kinase (MAPK) pathway was also involved in the signaling of GLP-1R ( in vitro study with peripheral blood mononuclear cells, exendin-4 suppressed inflammatory responses and reduced oxidative stress, which was rmediated by suppressing MAPK signaling pathway ( 3.3 PI3K/Akt pathway GLP-1RAs can also function through the Phosphoinositide 3-kinases (PI3K)/AKT pathway ( in vitro and vivo
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At same time, the content of IL-10 was visibly reduced from 144.8 7.09 pg/mL (n = 8) in the control group to 114.3 5.91 pg/mL about 21.06% (p = 0.002, n = 9), 111.8 4.16 pg/ml about of 22.79% (p = 0.004, n = 9) at RE doses of 3 g/kg and 6 g/kg, respectively
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