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SARS-CoV-2 ORF3a constitutes a distinctive viral protein capable of interacting with STING, consequently disrupting the STING-LC3 association and impeding cGAS-STING-mediated autophagy, whilst preserving IRF3-Type I IFN induction

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This off-target binding is the likely contributor to its cortisol and ACTH co-secretion, as it stimulates the hypothalamic-pituitary-adrenal axis in addition to the GH axis

doi: 10.1016/j.cell.2012.12.018 149 IncalcaterraSDominguezJA

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