These include anorectic effects driven by previously discussed central modulation of satiety and reward pathways and peripheral activation of vagal afferents, delayed gastric emptying, anti-inflammatory properties, potential impact on energy expenditure and the ability to reduce ghrelin levels, which are inherently elevated in PWS ( 2 to 11.3 kg/m 2 ( 2 in 10/14 cases, and an HbA1c improvement in 19/23 cases, without reported serious side effects ( Semaglutide at a dose of 2.4 mg weekly is the first weekly long-acting GLP-1 RA approved for non-syndromic obesity treatment with a mean weight change of 14.9% in individuals with obesity without diabetes ( Our case series presents the long-term efficacy and safety of semaglutide treatment in patients with PWS without diabetes as well as semaglutide efficacy and safety in PWS previously treated with metabolic surgery
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The rapid glucose load may also cause blood sugar fluctuations, particularly in patients taking concurrent diabetes medications like insulin or sulfonylureas, which could compound feelings of nausea or discomfort
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Another study reached similar conclusions, noting that when taken together, HRT helps preserve muscle and reduce belly fat, while semaglutide (Wegovy) lowers appetite and insulin sensitivity
