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We constructed the naltrexone/topiramate cohort to compare semaglutide to naltrexone/topiramate for recurrent AUD risk in patients with obesity

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5, 6 This indicates that it is the size of reduction in free leptin, from before the weight loss to 52 weeks after weight loss, rather than the absolute post-weight loss values that control food-seeking behavior

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doi:10.1016/S0140-6736(13)62062-0