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Duodenal nutrient exposure contributes to enhancing gastric accommodation

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inherited conditions may also cause dementia alongside other features include: Alexander disease, Canavan disease, cerebrotendinous xanthomatosis, fragile X-associated tremor/ataxia syndrome, glutaric aciduria type 1 , Krabbe's disease, maple syrup urine disease, Niemann Pick disease type C, ufs' disease, neuroacanthocytosis, organic acidemias, Pelizaeus-Merzbacher disease, urea cycle disorders, Sanfilippo syndrome type B, and spinocerebellar ataxia type 2

The C allele alone has minimal physiological impact, but when combined with C677T, it reduces MTHFR activity and folate levels, raising homocysteine

PMID: 15134286 Heffernan MA et al