Considering the significantly elevated expression levels of GLP-1R in diabetic patients, it is hypothesized that administration of GLP-1R agonists may elevate the risk of breast cancer progression in these patients, thus necessitating particular caution in clinical management [101]
For patients with a body mass index over 40, or 35 with comorbidities, bariatric surgery is safe and effective
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The international clinical development of efpeglenatide was stopped, despite being the only exendin derivative that, in a (terminated) phase 3 RCT, showed kidney benefit [HR 0.68 (95% CI 0.570.79)] and a reduction in the primary MACE outcome in T2DM patients with a history of CVD or CKD plus at least one other cardiovascular risk factor [57]
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