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Sermorelin, due to its structural similarity to endogenous hypothalamic signals, has been theorized to provide insight into how hypothalamic peptides regulate pituitary signaling dynamics

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For example, increased INS promoter methylation levels and INS mRNA suppression were observed under over-nutrition conditions and obese T2DM patients

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As an additional control, we further included a group of GLP-1GIP-treated mice that were additionally food-restricted to match the body weight of the GLP-1GIPLani-treated mice