[26] A complication of severe chronic PA is subacute combined degeneration of spinal cord, which leads to distal sensory loss (posterior column), absent ankle reflex, increased knee reflex response, and extensor plantar reflex response
Specifically, the relentless wear-and-tear from reactive oxygen species (ROS) and chronic low-grade inflammation
Just a small sting as the needle went in and then blissful nothing
As a result, there is still a gap in diagnostic knowledge, as it remains uncertain whether specific longitudinal metabolic changes can accurately predict the progression from MCI to AD or provide insights into the underlying molecular mechanisms
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