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doi: 10.3389/fendo.2026.1800681 Received 31 January 2026 Revised 02 March 2026 Accepted 04 March 2026 Published 20 March 2026 Volume 17 - 2026 Edited by Martine Culty, University of Southern California, United States Reviewed by Jiangang Hou, Fudan University, China Leyla Aydn, Yildirim Beyazit University Yenimahalle Training and Research Hospital, Trkiye Updates Copyright 2026 Qin, Wu, Mo, Shen, Tan, Li, He and Peng

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Compared to contrast enhanced DCE-MRI, ASL may be more sensitive to subtle BBB breakdown given the smaller size of water molecules compared to gadolinium contrast agents (Figure 2)