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Importantly a methyl block or methyl trapping can be a major cause of anxiety, depression, headaches, migraines and the like because methylfolate is being trapped and not able to be incorporated into the methionine cycle for use

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These findings have been corroborated by others, who have demonstrated elevated IFP in invasive ductal carcinomas relative to benign tumors or noninvasive carcinomas and a positive correlation between tumor size and IFP [12]

doi: 10.1371/journal.pntd.0010724 46 JulienJLeparc-GoffartILinaBFuchsFForaySJanatovaIet al

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