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Opposition from anti-tobacco organizations, health and medical associations, and, in particular, a quartet of federal entitiesthe surgeon general, the Centers for Disease Control and Prevention, the National Institutes of Health, and the Food and Drug Administration (FDA)has slowed transition, left consumers disorientated, protected the cigarette trade, and damaged or destroyed hundreds of pro-health businesses

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A gradual increase from 150 mg per day for three days to 300 mg per day helps to minimize the side effects (Physicians Desk Reference, 2011)

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